Journal
GENES & DEVELOPMENT
Volume 31, Issue 10, Pages 1054-1065Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.297424.117
Keywords
Drosophila; Eph; Ephrin; dendrite; wiring
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology in Japan
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Japan Agency for Medical Research and Development (AMED)-CREST
- AMED
- Naito Foundation
- Grants-in-Aid for Scientific Research [15H04375] Funding Source: KAKEN
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Proper function of the neural network results from the precise connections between axons and dendrites of presynaptic and postsynaptic neurons, respectively. In the Drosophila olfactory system, the dendrites of projection neurons (PNs) stereotypically target one of similar to 50 glomeruli in the antennal lobe (AL), the primary olfactory center in the brain, and form synapses with the axons of olfactory receptor neurons (ORNs). Here, we show that Eph and Ephrin, the well-known axon guidance molecules, instruct the dendrodendritic segregation during the discrete olfactory map formation. The Eph receptor tyrosine kinase is highly expressed and localized in the glomeruli related to reproductive behavior in the developing AL. In one of the pheromone-sensing glomeruli (DA1), the Eph cell-autonomously regulates its dendrites to reside in a single glomerulus by interacting with Ephrins expressed in adjacent PN dendrites. Our data demonstrate that the trans interaction between dendritic Eph and Ephrin is essential for the PN dendritic boundary formation in the DA1 olfactory circuit, potentially enabling strict segregation of odor detection between pheromones and the other odors.
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