Journal
GENES & DEVELOPMENT
Volume 31, Issue 15, Pages 1529-1534Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.302570.117
Keywords
CD26; cell senescence; human diploid fibroblasts
Categories
Funding
- National Institute on Aging
- National Cancer Institute Intramural Research Program
- National Institutes of Health
- Japan Society for the Promotion of Science [15H04879, 15K15324, 16H05345, 16K09878]
- [S1311011]
- [150401-01]
- Grants-in-Aid for Scientific Research [15K15324, 16H05345, 16K09878, 15H04879] Funding Source: KAKEN
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Senescent cell accumulation in aging tissues is linked to age-associated diseases and declining function, prompting efforts to eliminate them. Mass spectrometry analysis revealed that DPP4 (dipeptidyl peptidase 4) was selectively expressed on the surface of senescent, but not proliferating, human diploid fibroblasts. Importantly, the differential presence of DPP4 allowed flow cytometry-mediated isolation of senescent cells using anti-DPP4 antibodies. Moreover, antibody-dependent cell-mediated cytotoxicity (ADCC) assays revealed that the cell surface DPP4 preferentially sensitized senescent, but not dividing, fibroblasts to cytotoxicity by natural killer cells. In sum, the selective expression of DPP4 on the surface of senescent cells enables their preferential elimination.
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