Journal
GENES & DEVELOPMENT
Volume 31, Issue 2, Pages 127-140Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.293704.116
Keywords
adipocyte precursor; adipogenesis; beige adipocytes; brown adipocytes; white adipocytes
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Funding
- National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK104789]
- National Institutes of Health National Institute of General Medical Sciences [T32 GM008203]
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The ability to maintain and expand the pool of adipocytes in adults is integral to the regulation of energy balance, tissue/stem cell homeostasis, and disease pathogenesis. For decades, our knowledge of adipocyte precursors has relied on cellular models. The identity of native adipocyte precursors has remained unclear. Recent studies have identified distinct adipocyte precursor populations that are physiologically regulated and contribute to the development, maintenance, and expansion of adipocyte pools in mice. With new tools available, the properties of adipocyte precursors can now be defined, and the regulation and function of adipose plasticity in development and physiology can be explored.
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