Journal
GENES & DEVELOPMENT
Volume 31, Issue 11, Pages 1073-1088Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.298232.117
Keywords
MCM2-7; DNA replication; pre-RC; CMG; replisome; cryo-EM
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/M003760/1, BB/N000323/1]
- Medical Research Council [MC_U120085811]
- Wellcome Trust [107903/Z/15/Z]
- Biotechnology and Biological Sciences Research Council [BB/M003760/1, BB/N000323/1] Funding Source: researchfish
- Medical Research Council [MC_U120085811, 1583051] Funding Source: researchfish
- Wellcome Trust [107903/Z/15/Z] Funding Source: researchfish
- Wellcome Trust [107903/Z/15/Z] Funding Source: Wellcome Trust
- BBSRC [BB/N000323/1, BB/M003760/1] Funding Source: UKRI
- MRC [MC_U120085811] Funding Source: UKRI
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DNAreplication results in the doubling of the genome prior to cell division. This process requires the assembly of 50 or more protein factors into a replication fork. Here, we review recent structural and biochemical insights that start to explain how specific proteins recognize DNA replication origins, load the replicative helicase on DNA, unwind DNA, synthesize newDNAstrands, and reassemble chromatin. We focus on the minichromosome maintenance (MCM2-7) proteins, which form the core of the eukaryotic replication fork, as this complex undergoes major structural rearrangements in order to engage with DNA, regulate its DNA-unwinding activity, and maintain genome stability.
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