Journal
GENES & DEVELOPMENT
Volume 31, Issue 2, Pages 88-100Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.294769.116
Keywords
3 ' to 5 '; RNA degradation; RNA exosome; RNA processing; endoribonuclease; exoribonuclease; exosome
Categories
Funding
- National Institutes of Health/National Institute of General Medical Sciences [R01GM079196, R35GM118080, P30 CA008748]
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The eukaryotic RNA exosome is an essential and conserved protein complex that can degrade or process RNA substrates in the 3'- to- 5' direction. Since its discovery nearly two decades ago, studies have focused on determining how the exosome, along with associated cofactors, achieves the demanding task of targeting particular RNAs for degradation and/or processing in both the nucleus and cytoplasm. In this review, we highlight recent advances that have illuminated roles for the RNA exosome and its cofactors in specific biological pathways, alongside studies that attempted to dissect these activities through structural and biochemical characterization of nuclear and cytoplasmic RNA exosome complexes.
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