Journal
GENES & DEVELOPMENT
Volume 31, Issue 13, Pages 1289-1301Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.303149.117
Keywords
RNA polymerase II; core promoter; core promoter elements; sequence-specific transcription factors; TBP; TBP-related factors; chromatin
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Funding
- University of California at San Diego Molecular Biology Cancer Center Fellowship
- National Institutes of Health [R35 GM118060, R21 HG008781]
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The signals that direct the initiation of transcription ultimately converge at the core promoter, which is the gateway to transcription. Here we provide an overview of the RNA polymerase II core promoter in bilateria (bilaterally symmetric animals). The core promoter is diverse in terms of its composition and function yet is also punctilious, as it acts with strict rules and precision. We additionally describe an expanded view of the core promoter that comprises the classical DNA sequence motifs, sequence-specific DNA-binding transcription factors, chromatin signals, and DNA structure. This model may eventually lead to a more unified conceptual understanding of the core promoter.
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