Journal
GENES & DEVELOPMENT
Volume 31, Issue 12, Pages 1180-1194Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.301325.117
Keywords
DNA damage; nervous system; genome stability; neurodevelopment; neurologic disease
Categories
Funding
- National Institutes of Health [NS-37956, CA-21765]
- Cancer Center Support Grant [P30 CA21765]
- American Lebanese and Syrian Associated Charities of St. Jude Children's Research Hospital
Ask authors/readers for more resources
Multiple DNA repair pathways maintain genome stability and ensure that DNA remains essentially unchanged over the life of a cell. Various human diseases occur if DNA repair is compromised, and most of these impact the nervous system, in some cases exclusively. However, it is often unclear what specific endogenous damage underpins disease pathology. Generally, the types of causative DNA damage are associated with replication, transcription, or oxidative metabolism; other direct sources of endogenous lesions may arise from aberrant topoisomerase activity or ribonucleotide incorporation into DNA. This review focuses on the etiology of DNA damage in the nervous system and the genome stability pathways that prevent human neurologic disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available