Journal
GENES & DEVELOPMENT
Volume 31, Issue 8, Pages 719-720Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.300491.117
Keywords
sumoylation; desumoylation; STUbL; monopolin; cohibin; rDNA silencing; RENT complex
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Funding
- National Institutes of Health [GM080670]
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SUMO homeostasis is important for many cellular processes. In the current issue of Genes & Development, Liang and colleagues (pp. 802-815) demonstrate how a desumoylation enzyme is targeted to the nucleolus for removing SUMO from specific substrates and how curtailing sumoylation levels can regulate transcription in this nuclear compartment.
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