Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation

Hosts with compromised or naive immune systems, such as individuals living with HIV/AIDS, transplant recipients, and fetuses, are at the highest risk for complications from cytomegalovirus (CMV) infection. Despite substantial progress in prevention, diagnostics, and treatment, CMV continues to negatively impact both solid-organ transplant (SOT) and hematologic cell transplant (HCT) recipients. In this article, we summarize important developments in the field over the past 10 years and highlight new approaches and remaining challenges to the optimal control of CMV infection and disease in transplant settings.

Automated summary

Individuals with compromised immune systems are at the highest risk for complications from CMV infection, including those living with HIV/AIDS, transplant recipients, and fetuses. Despite significant progress in prevention, diagnostics, and treatment, there are challenges in optimal control of CMV infection and disease in transplant settings.