Journal
MOVEMENT DISORDERS
Volume 36, Issue 3, Pages 681-689Publisher
WILEY
DOI: 10.1002/mds.28364
Keywords
third ventricle width; Parkinson' s disease; progressive supranuclear palsy; MRI biomarker; clinical practice
Categories
Funding
- Michael J. Fox Foundation for Parkinson's Research
- AbbVie
- Allergan
- Amathus Therapeutics
- Avid Radiopharmaceuticals
- Biogen
- BioLegend
- Bristol-Myers Squibb
- Celgene
- Denali
- GE Healthcare
- Genentech
- GlaxoSmithKline
- Handl Therapeutics
- Insitro
- Janssen Neuroscience
- Lilly
- Lundbeck
- Merck
- Meso Scale Discovery
- Pfizer
- Piramal
- Prevail Therapeutics
- Roche
- Sanofi Genzyme
- Servier
- Takeda
- Teva
- UCB
- Verily
- Voyager Therapeutics
- Golub Capital
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The measurement of third ventricle width can distinguish Parkinson's disease (PD) from progressive supranuclear palsy (PSP).
Background Enlargement of the third ventricle has been reported in atypical parkinsonism. We investigated whether the measurement of third ventricle width could distinguish Parkinson's disease (PD) from progressive supranuclear palsy (PSP). Methods We assessed a new MR T1-weighted measurement (third ventricle width/internal skull diameter) in a training cohort of 268 participants (98 PD, 73 PSP, 98 controls from our center) and in a testing cohort of 291 participants (82 de novo PD patients and 133 controls from the Parkinson's Progression Markers Initiative, 76 early-stage PSP from an international research group). PD diagnosis was confirmed after a 4-year follow-up. Diagnostic performance of the third ventricle/internal skull diameter was assessed using receiver operating characteristic curve with bootstrapping; the area under the curve of the training cohort was compared with the area under the curve of the testing cohort using the De Long test. Results In both cohorts, third ventricle/internal skull diameter values did not differ between PD and controls but were significantly lower in PD than in PSP patients (P < 0.0001). In PD, third ventricle/internal skull diameter values did not change significantly between baseline and follow-up evaluation. Receiver operating characteristic analysis accurately differentiated PD from PSP in the training cohort (area under the curve, 0.94; 95% CI, 91.1-97.6; cutoff, 5.72) and in the testing cohort (area under the curve, 0.91; 95% CI, 87.0-97.0; cutoff,: 5.88), validating the generalizability of the results. Conclusion Our study provides a new reliable and validated MRI measurement for the early differentiation of PD and PSP. The simplicity and generalizability of this biomarker make it suitable for routine clinical practice and for selection of patients in clinical trials worldwide. (c) 2020 International Parkinson and Movement Disorder Society
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