Journal
GENERAL AND COMPARATIVE ENDOCRINOLOGY
Volume 246, Issue -, Pages 46-50Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2017.03.011
Keywords
Thymus; POMC-derived peptides; Apoptosis; Evolution
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Funding
- Department of Life Sciences, University of Modena and Reggio Emilia (Modena, Italy)
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From an evolutionary point of view, the thymus is a new organ observed for the first time in fish concomitantly with the appearance of adaptive clonotypical immunity. Hormone and neuropeptide expression was demonstrated in different species suggesting a conserved role of these molecules. An integrated evolution of immune and neuroendocrine responses appears to have been realized by means of the re-use of ancestral material, such as neuroendocrine cells and mediators, to create a thymic microenvironment for the maturation and differentiation of T cells. (C) 2017 Published by Elsevier Inc.
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