Journal
GENERAL AND COMPARATIVE ENDOCRINOLOGY
Volume 249, Issue -, Pages 40-47Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2017.02.018
Keywords
AMPK; HFD preference; Glucocorticoids; Neuropeptides
Categories
Funding
- National Key Research Program of China [2016YFD0500510]
- Natural Science Foundation of Shandong Province [ZR2014CP028]
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Glucocorticoids (GCs) stimulate appetite, contributing to enhanced fat deposition. Our present study was conducted to determine whether GCs could evoke an appetite specifically for fat-rich diets in chicks. Chicks were subjected to a subcutaneous injection of corticosterone (CORT, 2 mg/kg body weight/day) or corn oil (control), and food preference was tested. The results showed that CORT-chicks consumed more high-fat diet (HFD) compared with controls. In HFD-fed chicks, hypothalamic phosphorylated AMP-activated protein kinase a (AMPKa) and neuropeptide Y (NPY) mRNA levels were increased by CORT treatment. Activating AMPK with 5-aminoimidazole-4-carboxamide-1-13-n-ribofuranoside, an AMPK activator, via intracerebroventricular injection further enhanced the CORT-induced HFD consumption and concurrently up-regulated NPY mRNA levels and phosphorylated AMPKa and acetyl-coenzyme A carboxylase levels. The dramatic increase in HFD consumption and upregulation of NPY mRNA levels and phospho-AMPKa levels induced by peripheral CORT injection was not altered by intracerebroventricular infusion of compound C (4-16 mu g), an AMPK inhibitor. In conclusion, CORT challenge caused a HFD preference by enhancing the AMPK pathway in the hypothalamus. (C) 2017 Elsevier Inc. All rights reserved.
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