Dynamical properties and path dependence in a gene-network model of cell differentiation

In this work, we explore the properties of a control mechanism exerted on random Boolean networks that takes inspiration from the methylation mechanisms in cell differentiation and consists in progressively freezing (i.e. clamping to 0) some nodes of the network. We study the main dynamical properties of this mechanism both theoretically and in simulation. In particular, we show that when applied to random Boolean networks, it makes it possible to attain dynamics and path dependence typical of biological cells undergoing differentiation.

Automated summary

In this study, a control mechanism inspired by methylation mechanisms in cell differentiation was explored to exert influence on random Boolean networks. It was found that when applied to these networks, the mechanism enabled the attainment of dynamics and path dependence typical of biological cells undergoing differentiation.