Journal
COLLOID AND POLYMER SCIENCE
Volume 299, Issue 1, Pages 129-136Publisher
SPRINGER
DOI: 10.1007/s00396-020-04778-2
Keywords
Chondroitin sulfate A; Doxorubicin; Polymer-drug conjugate; Self-assembled nanoparticles
Categories
Funding
- Natural Science Foundation of Jiangxi Province [20192ACBL20032, 20202BABL206155]
- Scientific Research Fund of Education Department of Jiangxi Province [GJJ180900]
- Scientific Research Fund of Health Commission of Jiangxi Province [20195632, 20204271]
- Jiujiang ShuangBai-ShuangQian Talents Plan [8400842]
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A novel chondroitin sulfate A conjugated doxorubicin (CSA-DOX) was synthesized and characterized, with a mean diameter of 152 nm. The CSA-DOX/DOX nanoparticles exhibited enhanced cellular uptake of DOX into CD44 receptor-positive A549 cells, leading to significant cytotoxicity improvement against the cells.Results indicated that CSA-DOX copolymer could be a potential carrier for antitumor drug delivery.
Novel chondroitin sulfate A conjugated doxorubicin (CSA-DOX) was synthesized and characterized. The mean diameter of CSA-DOX was 152 nm analyzed by dynamic light scattering (DLS). Further, DOX was physically encapsulated into the CSA-DOX nanoparticles. Total amounts of DOX in three kinds of DOX-loaded CSA-DOX (CSA-DOX/DOX) nanoparticles were from 21.8 to 24.2%. The mean diameters of three CSA-DOX/DOX nanoparticles were in the range of 167-177 nm. The shape of CSA-DOX/DOX nanoparticles was almost spherical. DOX released from DOX-loaded nanoparticles exhibited a biphasic way in phosphate buffered saline (PBS, pH 7.4). Cellular uptake studies exhibited that CSA-DOX and CSA-DOX/DOX nanoparticles could enhance the uptake of DOX into CD44 receptor-positive A549 cells. Moreover, the cytotoxicity of CSA-DOX/DOX nanoparticles against A549 cells significantly improved in contrast with free DOX and CSA-DOX nanoparticles. These results suggested that CSA-DOX copolymer could be a potential carrier for antitumor drug delivery.
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