Antimicrobial and antioxidant chlorinated azaphilones from mangrove Diaporthe perseae sp. isolated from the stem of Chinese mangrove Pongamia pinnata

Many plants remain unexplored for their endophytic fungi that may possess potentially important phytochemicals. Consequently, we have focused to discover new natural products from endophytic fungus Diaporthe perseae sp. isolated from the stem of the Chinese mangrove Pongamia pinnata (L.) Pierre plant that led to the isolation of one new chlorinated isochromophilone G (1) along with six known azaphilones (2-7). The structures of the isolated compounds were elucidated by UV, NMR and Mass spectroscopic analysis. All the isolated compounds were screened for their antimicrobial and anti-oxidant activities.

Automated summary

In this study, a new chlorinated isochromophilone G and six known azaphilones were isolated from the endophytic fungus Diaporthe perseae sp. from the stem of the Chinese mangrove Pongamia pinnata. The structures of the isolated compounds were identified through UV, NMR, and Mass spectroscopic analysis, and all compounds were screened for their antimicrobial and anti-oxidant activities.