Journal
ARCHIV DER PHARMAZIE
Volume 354, Issue 2, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.202000231
Keywords
allergy; cytokines; docking; histamine; NF‐ ĸ B
Funding
- Shaanxi Provincial Education Department [12JK0733]
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Corynoline (COR) shows protective effects against ovalbumin (OVA)-induced allergic rhinitis (AR) in mice by reducing histamine intensity, cytokine levels, and NF-kappa B binding activity. The findings suggest that COR could be a potential therapeutic agent for AR.
Allergic rhinitis (AR) is a serious public health concern worldwide. Therefore, the present study was conducted to scrutinize the protective effect of corynoline (COR) against ovalbumin (OVA)-induced AR in BALB/c mice. The effect of COR was investigated on various parameters, such as nose-rub score, histamine intensity, level of cytokines, and NF-kappa B binding activity. It was found that COR causes a significant reduction in the nose-rub score with a reduction in histamine intensity. It also causes reductions in cytokines, such as TNF-alpha, IL-1 beta, and MIP-2, in comparison to OVA-challenged mice. COR reduces the gene expression of active caspase-1 in Western blot analysis, together with inhibition of NF-kappa B binding activity. The inhibitory effect on NF-kappa B binding was further substantiated by docking analysis, where COR excellently docked into the active site of NF-kappa B via the creation of H-bond and pi-cation interactions with Lys145. Taken altogether, our results demonstrated that COR could be used as a potential therapeutic agent against AR.
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