Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 30, Issue 1, Pages 196-214Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-020-02650-0
Keywords
Araucaria columnaris (G. Forst.) ) Hook; Phytochemical; Antioxidant; RP-HPLC-DAD and GC-MS; DFT
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This study aimed to explore the phytochemical composition, antioxidant potential, and DFT analysis of Araucaria columnaris (G. Forst.) Hook. leaves. Methanolic extracts showed the highest antioxidant values among the three solvents used for extraction. Furthermore, a total of 48 bioactive compounds were identified in methanol, chloroform, and hexane extracts using GC-MS technique.
The present study was aimed to explore the phytochemical composition, antioxidant potential, and density function theory (DFT) study of Araucaria columnaris (G. Forst.) Hook. leaves. Different extraction techniques like Soxhlet, ultrasound, and maceration were performed using solvents-hexane, chloroform, and methanol. Among the three solvents, the best antioxidant values were observed in methanolic extracts followed by chloroform and hexane. The results of RP-HPLC-DAD showed the 11 polyphenolic compounds in methanolic extracts. The observed order of yield, polyphenolic content and antioxidant potential in three techniques was SOX > ULT > MCE. For the first time, 48 bioactive compounds were identified in methanol, chloroform, and hexane extracts using GC-MS technique. DFT has been carried out on major phytochemicals of methanol extract at B3LYP/6-31G (d) basis set (Gaussian 09 program). The obtained results concluded that the A. columnaris (G. Forst.) Hook. leaves contained the distinct phytochemicals having ethnopharmacological employments and significant antioxidant potential. [GRAPHICS]
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