Journal
GENE
Volume 611, Issue -, Pages 27-37Publisher
ELSEVIER
DOI: 10.1016/j.gene.2017.02.025
Keywords
KLF4; Gene expression; Transcription; Tissues; Organs; Diseases; Proliferation; Differentiation; Cell cycle; Stem cells; Inflammation; Cancer; Epithelial-to-mesenchymal transition
Categories
Funding
- National Institutes of Health [GM089820]
- Elsevier, the publisher of GENE
- National Institutes of Helath [CA084197, DK052230]
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Kruppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation. Since its discovery in 1996, KLF4 has been gaining a lot of attention, particularly after it was shown in 2006 as one of four factors involved in the induction of pluripotent stem cells (iPSCs). Here we review the current knowledge about the different functions and roles of KLF4 in various tissue and organ systems. (C) 2017 Elsevier B.V. All rights reserved.
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