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Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways
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PET imaging of CXCR4 using copper-64 labeled peptide antagonist
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KOREAN JOURNAL OF UROLOGY (2011)
Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis
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Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome
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Expression pattern of stromal cell-derived factor-1 chemokine in invasive breast cancer is correlated with estrogen receptor status and patient prognosis
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Disruption of the Blood Brain Barrier by Brain Metastases of Triple-Negative and Basal-Type Breast Cancer But Not HER2/neu-Positive Breast Cancer
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FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis
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CXC Chemokine Receptor 4 Is a Cell Surface Receptor for Extracellular Ubiquitin
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
PET of Tumor CXCR4 Expression with 4-18F-T140
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JOURNAL OF NUCLEAR MEDICINE (2010)
A CXCR4 Antagonist CTCE-9908 Inhibits Primary Tumor Growth and Metastasis of Breast Cancer (vol 155, pg 231, 2009)
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JOURNAL OF SURGICAL RESEARCH (2010)
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
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FDA Review Summary: Mozobil in Combination with Granulocyte Colony-Stimulating Factor to Mobilize Hematopoietic Stem Cells to the Peripheral Blood for Collection and Subsequent Autologous Transplantation
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Selective Enhancement of Donor Hematopoietic Cell Engraftment by the CXCR4 Antagonist AMD3100 in a Mouse Transplantation Model
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CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells
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Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
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Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
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SCIENCE (2010)
Androgens Induce Functional CXCR4 through ERG Factor Expression in TMPRSS2-ERG Fusion-Positive Prostate Cancer Cells
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)
PET imaging of tumor CXCR4 expression with 18F-T140
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ANNALS OF ONCOLOGY (2009)
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64Cu-AMD3100-A novel imaging agent for targeting chemokine receptor CXCR4
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CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling
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Positive Feedback Activation of Estrogen Receptors by the CXCL12-CXCR4 Pathway
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CANCER RESEARCH (2009)
Imaging chemokine receptor dimerization with firefly luciferase complementation
Kathryn E. Luker et al.
FASEB JOURNAL (2009)
Diversity in T Cell Memory: An Embarrassment of Riches
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IMMUNITY (2009)
Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of Selective Antagonists
Denis Sohy et al.
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The CXCL12 (SDF-1)/CXCR4 Axis Is Essential for the Development of Renal Vasculature
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AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties
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Effects of CXCR4 Antagonist CTCE-9908 on Prostate Tumor Growth
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Eugene H. Huang et al.
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Steven M. Devine et al.
BLOOD (2008)
New insights into the role of CXCR4 in prostate cancer metastasis
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Synthesis and application of fluorescein- and biotin-labeled molecular probes for the chemokine receptor CXCR4
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CANCER AND METASTASIS REVIEWS (2007)
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EXPERT REVIEW OF ANTICANCER THERAPY (2007)
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CXCR4 engagement promotes dendritic cell survival and maturation
Kenji Kabashima et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
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Bicalutamide increases phospho-Akt levels through Her2 in patients with prostate cancer
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CELL STEM CELL (2007)
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WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4
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The Gα13-Rho signaling axis is required for SDF-1-induced migration through CXCR4
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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)
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Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
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CXCR4 physically associates with the T cell receptor to signal in T cells
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Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis
V Ödemis et al.
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The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
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Fugetaxis: active movement of leukocytes away from a chemokinetic agent
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Dendritic-cell trafficking to lymph nodes through lymphatic vessels
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Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells
A Kortesidis et al.
BLOOD (2005)
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
A Orimo et al.
CELL (2005)
Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers
Y Percherancier et al.
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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
R Stupp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo
YX Sun et al.
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Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl) alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131
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CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo
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Expression of the chemokine receptors CXCR4 and CCR7 and, disease progression in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma
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Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection
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Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer
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Interaction of ligand-receptor system between stromal-cell-derived factor-1 and CXC chemokine receptor 4 in human prostate cancer: a possible predictor of metastasis
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
CXCR4 regulates growth of both primary and metastatic breast cancer
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CANCER RESEARCH (2004)
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SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells
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CANCER CELL (2004)
Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV
R Sadir et al.
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Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
M Darash-Yahana et al.
FASEB JOURNAL (2004)
Regulation of the chemokine receptor CXCR4 by hypoxia
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JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease
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MOLECULAR ENDOCRINOLOGY (2003)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
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Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives
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ORGANIC & BIOMOLECULAR CHEMISTRY (2003)
Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)
Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma
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BREAST CANCER RESEARCH (2003)
Efficacious immunomodulatory activity of the chemokine stromal cell-derived factor 1 (SDF-1): local secretion of SDF-1 at the tumor site serves as T-cell chemoattractant and mediates T-cell-dependent antitumor responses
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BIOLOGICAL CHEMISTRY (2001)
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Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function
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Subsecond induction of α4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions
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