Journal
GENE
Volume 630, Issue -, Pages 68-75Publisher
ELSEVIER
DOI: 10.1016/j.gene.2017.08.006
Keywords
Umbilical cord mesenchymal stem cells; Type II alveolar epithelial cells; Hypoxia; Transforming growth factor-beta; MicroRNA-145
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Funding
- Special Research Foundation of the First Hospital of Jilin University [A07]
- Jilin Province Science and Technology Agency [20160101037JC, 20170622009JC]
- Health Department Research Projects of Jilin Province [2017C021]
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Mesenchymal stem cells (MSCs) are well recognized for their ability to differentiate into type II alveolar epithelial (ATII) cells in damaged lungs, which is critical for reepithelization and recovery in acute lung injury (ALI). However, the high level of transforming growth factor-beta (TGF-beta) commonly seen in injured lung tissues is also able to induce MSCs to differentiate into fibroblast-like cells. In this study, we found that hypoxia could promote umbilical cord mesenchymal stem cells (UCMSCs) differentiation into ATII cells rather than into fibroblast-like cells, and this effect was mainly mediated by microRNA-145 (miR-145), which could induce the inhibition of TGF-beta signaling by targeting TGF-beta receptor II (TGF beta RII). Clarifying the function of hypoxia in the fate determination of MSCs is important for improving stem cell-based therapies for ALI.
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