Journal
JOURNAL OF RAMAN SPECTROSCOPY
Volume 52, Issue 2, Pages 412-419Publisher
WILEY
DOI: 10.1002/jrs.6008
Keywords
cucurbituril; repeatability; reproducibility; self‐ assembly; SERS | plasmonics
Categories
Funding
- EPSRC [EP/L027151/1, EP/P029426/1, EP/R020965/1]
- Trinity College, University of Cambridge
- EPSRC Centre for Doctoral Training in Sensor Technologies and Applications [EP/L015889/1]
- Winton Programme for the Physics of Sustainability
- Leverhulme Trust
- Isaac Newton Trust
- EPSRC [EP/R020965/1, EP/P029426/1, EP/L027151/1] Funding Source: UKRI
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Irreproducibility in SERS due to substrate variability is a major obstacle, but can be minimized by identifying and reducing sources, facilitating the transition of SERS from the lab to real-world applications.
Irreproducibility in surface-enhanced Raman spectroscopy (SERS) due to variability among substrates is a source of recurrent debate within the field. It is regarded as a major hurdle towards the widespread adoption of SERS as a sensing platform. Most of the literature focused on developing substrates for various applications considers reproducibility of lower importance. Here, we address and analyse the sources of this irreproducibility in order to show how these can be minimised. We apply our findings to a simple substrate demonstrating reproducible SERS measurements with relative standard deviations well below 1% between different batches and days. Identifying the sources of irreproducibility and understanding how to reduce these can aid in the transition of SERS from the lab to real-world applications.
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