Journal
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
Volume 24, Issue 2, Pages 159-169Publisher
WILEY
DOI: 10.1111/1756-185X.14021
Keywords
autoimmunity; exosome; rheumatoid arthritis; rheumatologic disorders
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Funding
- Mazandaran University of Medical Sciences
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Cell-derived exosomes play a crucial role in cell-cell communication and disease pathogenesis, especially in autoimmune disorders. Rheumatoid arthritis is an inflammation-based disease that requires further research, with current treatment options limited to symptom relief.
Cell-derived exosomes are identified as carriers of lipids, proteins, and genetic materials that participate in cell-cell signal communication, biological process, and cell signaling. Also, their involvement has been reported in a vast array of disorders and inflammatory conditions such as autoimmune diseases. Rheumatoid arthritis (RA), a common cause of joint disorder, is an inflammation-based disease in which the precise understanding of its pathogenesis needs to be further investigated. Also, there is only a palliative care approach for the alleviation of RA symptoms. This paper discusses the recent advances in the biology of exosomes in autoimmune disorders especially in RA, and also provides a new line of research for arthritis therapy using exosomes.
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