Journal
BIOESSAYS
Volume 43, Issue 2, Pages -Publisher
WILEY
DOI: 10.1002/bies.202000197
Keywords
junk RNA; lncRNA; mRNA; mRNA nuclear export; nuclear pore complex; NXF1; transcriptional noise; TREX
Categories
Funding
- Canadian Institutes of Health Research [FRN102725]
- Natural Sciences and Engineering Research Council of Canada [FN492860]
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The distribution pattern of GC-content in human protein-coding genes affects the nuclear export of mRNA, helping it to be recognized by the cellular machinery and promoting its export from the nucleus.
It has long been observed that human protein-coding genes have a particular distribution of GC-content: the 5 ' end of these genes has high GC-content while the 3 ' end has low GC-content. In 2012, it was proposed that this pattern of GC-content could act as an mRNA identity feature that would lead to it being better recognized by the cellular machinery to promote its nuclear export. In contrast, junk RNA, which largely lacks this feature, would be retained in the nucleus and targeted for decay. Now two recent papers have provided evidence that GC-content does promote the nuclear export of many mRNAs in human cells.
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