Journal
JOURNAL OF BIOPHOTONICS
Volume 14, Issue 2, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.202000324
Keywords
fluorescence; autofluorescence imaging; low‐ cost endoscopy; narrowband imaging; white‐ light imaging
Categories
Funding
- Projekt DEAL
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The study presents the development of a low-cost, reusable tethered capsule endoscopic platform for multi-mode imaging of the esophagus, with tests conducted on swine esophagus to demonstrate imaging capabilities and cost effectiveness. This device has the potential to provide esophagus imaging in underprivileged areas.
Multimodal low-cost endoscopy is highly desirable in poor resource settings such as in developing nations. In this work, we developed a smartphone-based low-cost, reusable tethered capsule endoscopic platform that allows white-light, narrowband, and fluorescence/autofluorescence imaging of the esophagus. The ex-vivo studies of swine esophagus were performed and compared with a commercial endoscope to test the white-light imaging capabilities of the endoscope. The efficacy of the capsule for narrow-band imaging was tested by imaging the vascularization of the tongue. To determine the autofluorescence/fluorescence capability of the endoscope, fluorescein dye with different concentrations was imaged. Furthermore, swine esophagus injected with fluorescein dye was imaged using the fluorescence/autofluorescence and the white-light imaging modules, ex-vivo. The overall cost of the capsules is approximately 12 euro, 15 euro, and 42 euro for the white light imaging, the narrow-band imaging, and the fluorescence/autofluorescence imaging respectively. In addition, the cost of the laser source module required for the narrow-band imaging and the fluorescence/autofluorescence imaging is approximately 218 euro. This device will open the possibility of imaging the esophagus in underprivileged areas.
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