Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 363, Issue 3, Pages 602-628Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202001017
Keywords
Mannich reaction; asymmetric catalysis; amines; oxidation; cross-dehydrogenative coupling
Categories
Funding
- Agencia Estatal de Investigacion (AEI, Spanish Government)
- Fondo Europeo de Desarrollo Regional (FEDER, European Union) [CTQ2017-84900-P]
- Ministerio de Ciencia, Innovacion y Universidades
- Agencia Estatal de Investigacion (AEI, Spanish Government) [RYC-2016-20187]
Ask authors/readers for more resources
This review summarizes recent publications on asymmetric oxidative Mannich reactions using amines as electrophiles, including the different oxidants used and the scope and limitations of the different catalytic systems.
The asymmetric Mannich reaction is one of the most straightforward methodologies for the enantioselective synthesis of chiral amines. In general, asymmetric Mannich reactions involve the use of imines as electrophiles. However, in recent years, several asymmetric oxidative Mannich reactions have been reported using amines as electrophiles. This review provides an overview of these recent publications, including the different oxidants used and the scope and limitations of the different catalytic systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
