Recent Advances in the Synthesis of Acyl Fluorides

Acyl fluorides are valuable intermediates in organic synthesis. They are increasingly employed in peptide synthesis, in challenging esterification and amidation reactions or in transition-metal-catalyzed transformations. This review summarizes recent advances in their preparation. 1 Introduction 2 Nucleophilic Fluorination 2.1.-Fluoroamine Reagents 2.2 Sulfur-Based Reagents 2.3 Metal Catalysts 2.4 Phosphorus-Based Reagents 2.5 N,N'-Dicyclohexylcarbodiimide/HF center dot Pyridine 2.6 Uranium Hexafluoride 2.7 Bromine Trifluoride 3 Radical Fluorination 4 Conclusion

Automated summary

This review summarizes recent advances in the preparation of acyl fluorides, including nucleophilic fluorination and radical fluorination methods, providing a reference for further research in the field of organic synthesis.