Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 148, Issue 3, Pages 759-768Publisher
WILEY
DOI: 10.1002/ijc.33358
Keywords
EBV positive; gastric cancer; LAG‐ 3; MLH1 defective; prognosis
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Funding
- National Natural Science Foundation of China [31770851, 81871930, 81902402, 81902901, 81972219, 82003019]
- Shanghai Sailing Program [17YF1402200, 18YF1404600, 19YF1407500]
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LAG-3, a transmembrane immune checkpoint, plays a role in immune escape in gastric cancer by suppressing T-cell-mediated anti-tumor immunity. Our study showed that LAG-3 expression was associated with poorer clinical outcomes in EBV-positive and MLH1-defective gastric cancer, suggesting it as a potential immunotherapeutic target.
Lymphocyte activation gene 3 (LAG-3) is a transmembrane immune checkpoint that facilitates immune escape via suppressing T-cell-mediated anti-tumor immunity. The role of LAG-3 in gastric cancer is little known. Consequently, we assessed the clinical significance of LAG-3 in gastric cancer. In our study, patients with gastric cancer from Zhongshan Hospital (n = 464) and data from the Asian Cancer Research Group (n = 300) were analyzed. LAG-3(+) cell infiltration and other immune contexture in gastric cancer were detected by immunohistochemistry. Kaplan-Meier curves and log-rank test were used for survival analyses. Intratumoral LAG-3(+) cells mainly accumulated in Epstein-Barr virus (EBV)-positive (EBV subtype) and MLH1-defective (dMLH1 subtype) gastric cancer. Furthermore, LAG-3(+) cell infiltration was strongly associated with inferior clinical outcomes in patients with these two subtypes of gastric cancer. Moreover, we found intratumoral LAG-3(+) cell high infiltration was associated with an immunoevasive contexture featured by decreased IFN-gamma(+) cells and perforin-1(+) cells, but increased regulatory T cells and M2-like macrophages in EBV/dMLH1 subtype of gastric cancer. LAG-3 was a poor prognostic factor and might be a potential immunotherapeutic target in EBV-positive and MLH1-defective gastric cancer.
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