Journal
POLYMERS FOR ADVANCED TECHNOLOGIES
Volume 32, Issue 3, Pages 1101-1113Publisher
WILEY
DOI: 10.1002/pat.5158
Keywords
capture; core‐ shell; CTC; electrospinning; hyaluronidase; nanofibers; release
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Funding
- National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran [750]
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A smart system is needed to identify the initiation of metastasis efficiently in order to prevent an increase in deaths due to the metastasis of primary tumors in many cancers. The early detection of cancer and using lower doses of drugs can lead to more efficient treatment with lower side effects, as shown by the efficacy of core-shell NFMs in capturing and releasing cancerous cells.
According to the increase of deaths due to the metastasis of primary tumors in many cancers, a smart system is required to recognize the initialization of metastasis, immediately and efficiently. In this paper, we introduce a novel platform based on the electrospun nanofibrous membranes (NFMs) for efficient capture of circulating tumor cells (CTCs) and then release them for further study. It is important to note that the detection of CTC must be specific and accurate to start treatment safely with the correct dose of the drug. The number of present CTCs in blood can determine the progress of cancer and its capability for metastasis. Therefore, the early detection of cancer and using lower doses of drugs leads to more efficient treatment with lower side effects of drugs, whereas the treatment of secondary tumors require more drug and cost. For this purpose, we generated a NFM from polycaprolactone/hyaluronic acid (HA) and with a core-shell structure to achieve CTC trapping with the application of early diagnosis of metastasis. Besides, we proved that the retrieval of these cells is possible using hyaluronidase. Our results demonstrated that the cancerous cell capture efficacy using this kind of core-shell NFMs is about 75% (compare to 25% in PCL NFM) which is a significant ratio. Also, it was proved that around 70% of these captured cells can release via hyaluronidase (in comparison with 20% for PCL NFM) with protecting their viability.
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