Journal
NEUROGASTROENTEROLOGY AND MOTILITY
Volume 33, Issue 8, Pages -Publisher
WILEY
DOI: 10.1111/nmo.14017
Keywords
achalasia; high‐ resolution manometry; jackhammer esophagus; nutcracker esophagus; opioid‐ induced peristalsis disorder; outflow obstruction
Funding
- Department of Medicine at the Medical College of Wisconsin
- Research and Education Program Fund, a component of the Advancing a Healthier Wisconsin Endowment at the Medical College of Wisconsin
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The study found that esophageal hypercontractility is associated with cholinergic hyperactivity rather than loss of inhibitory innervation. Atropine was able to abolish hypercontractility, while abnormal responses to CCK primarily occurred in patients with outflow obstruction.
Background Esophageal hypercontractility (EHC) is considered a major esophageal motor disorder of unclear etiology. Different mechanisms have been proposed, including an imbalance in inhibitory and excitatory esophageal innervation. We hypothesized that patients with EHC suffer from cholinergic hyperactivity. Aim To interrogate the excitatory and inhibitory neurotransmission in EHC by assessing the esophageal motor response to atropine (ATR) and cholecystokinin (CCK), respectively, in EHC patients. Method We retrospectively reviewed patients who underwent high-resolution manometry (HRM) with pharmacologic challenge in a tertiary referral center between 2007 and 2017. We identified 49 EHC patients who were categorized based on frequency of hypercontractile peristaltic sequence into frequent and infrequent and motility diagnosis groups. Deglutitive pressure metrics and esophageal motor responses to ATR (12 mcg/kg iv) and CCK (40 ng/kg iv) were analyzed across groups. Results Atropine abolished hypercontractility across all groups studied, converting nearly half of patients to a motor pattern of ineffective esophageal motility. Abnormal CCK responses primarily occurred in the patient groups with concomitant outflow obstruction. Conclusions Hypercontractility is cholinergically mediated in all esophageal motor disorders. Most patients with isolated EHC appear to have excessive cholinergic drive, rather than loss of inhibitory innervation, and might be candidates for treatment with anticholinergic agents.
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