Engineered trimeric ACE2 binds viral spike protein and locks it in Three-up conformation to potently inhibit SARS-CoV-2 infection

CELL RESEARCH

SPRINGERNATURE

1. Westlake Education Foundation
2. Tencent Foundation
3. National Megaprojects of China for Major Infectious Diseases [2018ZX10301403]
4. Natural Science Foundation of China [22077104, 32022037, 31971123, 81920108015, 31930059]
5. Key R&D Program of Zhejiang Province [2020C04001]
6. SARS-CoV-2 emergency project of the Science and Technology Department of Zhejiang Province [2020C03129]
7. Leading Innovative and Entrepreneur Team Introduction Program of Hangzhou