Journal
BIOMETALS
Volume 34, Issue 1, Pages 119-140Publisher
SPRINGER
DOI: 10.1007/s10534-020-00268-8
Keywords
Bioinorganic chemistry; Anticarcinogenic activity; Coumarin schiff base ligands; G-quadruplex DNA; Structure elucidation
Categories
Funding
- Departamento de Quimica, Facultad de Ciencias of the Universidad de los Andes [INV-2018-50-1354]
- Vicerrectoria de Investigaciones of the Universidad de los Andes [INV-2018-50-1354]
- Fondo de Apoyo para Profesores Asistentes
Ask authors/readers for more resources
The study synthesized eight novel metal complexes and evaluated their anticarcinogenic potential at the cellular level. The results showed that compounds 2 and 6 exhibited good anticancer effects on HeLa cells.
The synthesis of eight novel Zn(II), Co(II), Cu(II), Ni(II) and Pt(II) complexes (2-9) derived from the ONNO tetradentate coumarin Schiff-Base donor ligands, L-1 and the novel L-2, was performed. All compounds were characterized by analytical, spectrometry and spectroscopy techniques. Complexes 2-4 were also characterized by DFT calculations and the structures of 5 and 6 were determined by single-crystal X-ray diffraction analysis. A cytotoxicity study was carried out through an MTT assay in the carcinogenic cell line HeLa and the noncarcinogenic cell lines HFF-1 and HaCaT. The results indicated that among all the evaluated compounds, 2 and 6 presented the best anticarcinogenic potential against HeLa cells with an IC50 of 3.5 and 4.1 mu M, respectively. In addition, classical molecular dynamics simulations were performed on the synthesized coordination compounds bound to G4 DNA architectures in the scope of shedding light on their inhibition mode and the most conserved interactions that may lead to the biological activity of the compounds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available