In Vitro Release and Degradation Study of Letrozole-Loaded Poly(Lactic-co-Glycolic Acid) Microparticles

This work describes the stability and in vitro release of letrozole (drug)-loaded poly(lactic-co-glycolic acid) (PLGA) microparticles. To control the release capacity of the drug, the microparticles were fabricated with different ratios of biopolymer using solvent evaporation techniques. Further, the drug encapsulation efficiency, physicochemical properties, and morphologies were measured. In vitro release data of the drug were fitted to three theoretical models to evaluate the release kinetics. The highest correlation coefficient was found in Higuchi and Korsmeyer-Peppas that ensured the controlled release of the encapsulated drug from the microparticles. Scanning electron microscopy and Fourier-transform infrared spectroscopy analysis with gradual degradation time up to 80 days revealed the stability of PLGA, and stabilized the drug bioavailability.

Automated summary

This study investigated the stability and in vitro release of letrozole-loaded PLGA microparticles with different ratios of biopolymer. The release kinetics were evaluated using three theoretical models, with Higuchi and Korsmeyer-Peppas showing the highest correlation coefficients. Scanning electron microscopy and Fourier-transform infrared spectroscopy analysis confirmed the stability of PLGA and the drug bioavailability over an 80-day period.