Strategies for Delivering Nanoparticles across Tumor Blood Vessels

Nanoparticle transport across tumor blood vessels is a key step in nanoparticle delivery to solid tumors. However, the specific pathways and mechanisms of this nanoparticle delivery process are not fully understood. Here, the biological and physical characteristics of the tumor vasculature and the tumor microenvironment are explored and how these features affect nanoparticle transport across tumor blood vessels is discussed. The biological and physical methods to deliver nanoparticles into tumors are reviewed and paracellular and transcellular nanoparticle transport pathways are explored. Understanding the underlying pathways and mechanisms of nanoparticle tumor delivery will inform the engineering of safer and more effective nanomedicines for clinical translation.

Automated summary

Transporting nanoparticles across tumor blood vessels is crucial for delivering them to solid tumors, but the specific pathways and mechanisms of this process are not fully understood. The biological and physical characteristics of tumor vasculature and microenvironment play a role in affecting nanoparticle transport, and understanding these pathways and mechanisms can help in developing safer and more effective nanomedicines.