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Ying Wei et al.
GENOMICS PROTEOMICS & BIOINFORMATICS (2016)
Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma
Mouadh Benamar et al.
EBIOMEDICINE (2016)
The use of the NEDD8 inhibitor MLN4924 (Pevonedistat) in a cyclotherapy approach to protect wild-type p53 cells from MLN4924 induced toxicity
Lara J. Bou Malhab et al.
SCIENTIFIC REPORTS (2016)
Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study
Ronan T. Swords et al.
BRITISH JOURNAL OF HAEMATOLOGY (2015)
Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells
Yanchun Wang et al.
CANCER BIOLOGY & THERAPY (2015)
MLN4924, a novel protein neddylation inhibitor, suppresses proliferation and migration of human urothelial carcinoma: In vitro and in vivo studies
Kuan-Lin Kuo et al.
CANCER LETTERS (2015)
MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors
K. L. B. Knorr et al.
CELL DEATH AND DIFFERENTIATION (2015)
RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis
M. Zhang et al.
CELL DEATH AND DIFFERENTIATION (2015)
NEDD8 Inhibition Overcomes CKS1B-Induced Drug Resistance by Upregulation of p21 in Multiple Myeloma
Junwei Huang et al.
CLINICAL CANCER RESEARCH (2015)
Urmylation and tRNA thiolation functions of ubiquitin-like Uba4.Urm1 systems are conserved from yeast to man
Andre Juedes et al.
FEBS LETTERS (2015)
Knockdown of SUMO-activating enzyme subunit 2 (SAE2) suppresses cancer malignancy and enhances chemotherapy sensitivity in small cell lung cancer
Xiaoke Liu et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2015)
Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia
J. Khalife et al.
LEUKEMIA (2015)
Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth
Jonathan Levy et al.
NATURE CELL BIOLOGY (2015)
Protein neddylation: beyond cullin-RING ligases
Radoslav I. Enchev et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
Suppression of glioblastoma by targeting the overactivated protein neddylation pathway
Wei Hua et al.
NEURO-ONCOLOGY (2015)
Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation
Jun-Bao Fan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance
Lars Ketscher et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
SUMOylation-Mediated Regulation of Cell Cycle Progression anc Cancer
Karolin Eifler et al.
TRENDS IN BIOCHEMICAL SCIENCES (2015)
The demographics of the ubiquitin system
Michael J. Clague et al.
TRENDS IN CELL BIOLOGY (2015)
UBA1: At the Crossroads of Ubiquitin Homeostasis and Neurodegeneration
Ewout J. N. Groen et al.
TRENDS IN MOLECULAR MEDICINE (2015)
An inhibitor of ubiquitin conjugation and aggresome formation
Heeseon An et al.
CHEMICAL SCIENCE (2015)
The novel protective role of P27 in MLN4924-treated gastric cancer cells
Q. Zhang et al.
CELL DEATH & DISEASE (2015)
Targeting neddylation induces DNA damage and checkpoint activation and sensitizes chronic lymphocytic leukemia B cells to alkylating agents
C. Paiva et al.
CELL DEATH & DISEASE (2015)
Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure
Changwon Kho et al.
NATURE COMMUNICATIONS (2015)
Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma
Xiaoqi Xie et al.
CANCER DISCOVERY (2015)
Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model
Xuesen Li et al.
ONCOTARGET (2015)
Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer
Ping Chen et al.
ONCOTARGET (2015)
Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer
Lucia Barbier-Torres et al.
ONCOTARGET (2015)
MLN4924 Synergistically Enhances Cisplatin-induced Cytotoxicity via JNK and Bcl-xL Pathways in Human Urothelial Carcinoma
I-Lin Ho et al.
SCIENTIFIC REPORTS (2015)
Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites
Jessica S. Brown et al.
CELL REPORTS (2015)
UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development
Yafei Cai et al.
PLOS GENETICS (2015)
Atg7 in development and disease: panacea or Pandora's Box?
Jianhua Xiong
PROTEIN & CELL (2015)
A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver
Miyuki Suzawa et al.
ELIFE (2015)
ISG15: A double edged sword in cancer
Shyamal D. Desai
ONCOIMMUNOLOGY (2015)
Ubiquitin-fold modifier 1 acts as a positive regulator of breast cancer
Hee Min Yoo et al.
FRONTIERS IN ENDOCRINOLOGY (2015)
The NEDD8-Activating Enzyme Inhibitor MLN4924 Disrupts Nucleotide Metabolism and Augments the Efficacy of Cytarabine
Steffan T. Nawrocki et al.
CLINICAL CANCER RESEARCH (2015)
NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation
M. P. Licciardello et al.
ONCOGENE (2015)
Characterization of the Loss of SUMO Pathway Function on Cancer Cells and Tumor Proliferation
Xingyue He et al.
PLOS ONE (2015)
Structural and Functional Insights to Ubiquitin-Like Protein Conjugation
Frederick C. Streich et al.
ANNUAL REVIEW OF BIOPHYSICS, VOL 43 (2014)
Interferon-Stimulated Genes: A Complex Web of Host Defenses
William M. Schneider et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)
Targeting Protein-Protein Interaction by Small Molecules
Lingyan Jin et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 54 (2014)
Autophagy promotes BrafV600E-driven lung tumorigenesis by preserving mitochondrial metabolism
Anne M. Strohecker et al.
AUTOPHAGY (2014)
FAT10ylation as a signal for proteasomal degradation
Gunter Schmidtke et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)
Structure-based repurposing of FDA-approved drugs as inhibitors of NEDD8-activating enzyme
Hai-Jing Zhong et al.
BIOCHIMIE (2014)
MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells
Yanyan Gu et al.
BLOOD (2014)
The TAK1-NF-κB axis as therapeutic target for AML
Matthieu Cornelis Johannes Bosman et al.
BLOOD (2014)
Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma
Alexander Hoellein et al.
BLOOD (2014)
Ubiquitin-like Protein FAT10 Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Modifying β-Catenin Degradation
Rongfa Yuan et al.
CANCER RESEARCH (2014)
Isg15 controls p53 stability and functions
Yi-Fu Huang et al.
CELL CYCLE (2014)
SUMO-Mimicking Peptides Inhibiting Protein SUMOylation
Bo Zhao et al.
CHEMBIOCHEM (2014)
The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-κB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells
J. Claire Godbersen et al.
CLINICAL CANCER RESEARCH (2014)
UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells
Yasuyoshi Oka et al.
EMBO REPORTS (2014)
Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata
Misao Takemoto et al.
JOURNAL OF ANTIBIOTICS (2014)
A Complex between Atg7 and Caspase-9 A NOVEL MECHANISM OF CROSS-REGULATION BETWEEN AUTOPHAGY AND APOPTOSIS
Jie Han et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Mechanistic Study of Uba5 Enzyme and the Ufm1 Conjugation Pathway
James M. Gavin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Molecular dynamics investigation on the poor sensitivity of A171T mutant NEDD8-activating enzyme (NAE) for MLN4924
Sharad Verma et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2014)
Effective Virtual Screening Strategy toward Covalent Ligands: Identification of Novel NEDD8-Activating Enzyme Inhibitors
Shengping Zhang et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2014)
Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis
Hua Li et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Overactivated Neddylation Pathway as a Therapeutic Target in Lung Cancer
Lihui Li et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)
Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways
Khristofer Garcia et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Modification of ASC1 by UFM1 Is Crucial for ERα Transactivation and Breast Cancer Development
Hee Min Yoo et al.
MOLECULAR CELL (2014)
Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure
Julien Ablain et al.
NATURE MEDICINE (2014)
Targeting tumour-supportive cellular machineries in anticancer drug development
Matthias Dobbelstein et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Two-way communications between ubiquitin-like modifiers and DNA
Helle D. Ulrich
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
ISGylation governs the oncogenic function of Ki-Ras in breast cancer
J. Burks et al.
ONCOGENE (2014)
Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis
M. Tan et al.
ONCOGENE (2014)
Mutations in UBA3 Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Human Leukemic Cells
G. Wei Xu et al.
PLOS ONE (2014)
Extended lifespan and reduced adiposity in mice lacking the FAT10 gene
Allon Canaan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Disruption of FAT10-MAD2 binding inhibits tumor progression
Steven Setiawan Theng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
A potential antitumor ellagitannin, davidiin, inhibited hepatocellular tumor growth by targeting EZH2
Yan Wang et al.
TUMOR BIOLOGY (2014)
Suppression of tumor angiogenesis by targeting the protein neddylation pathway
W-T Yao et al.
CELL DEATH & DISEASE (2014)
Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles' heel in mantle cell lymphoma
M. A. Dengler et al.
CELL DEATH & DISEASE (2014)
SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression
Anita C. Bellail et al.
NATURE COMMUNICATIONS (2014)
Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target
Qiang Gao et al.
ONCOTARGET (2014)
The ROS/SUMO Axis Contributes to the Response of Acute Myeloid Leukemia Cells to Chemotherapeutic Drugs
Guillaume Bossis et al.
CELL REPORTS (2014)
The impact of the endoplasmic reticulum protein-folding environment on cancer development
Miao Wang et al.
NATURE REVIEWS CANCER (2014)
Quantifiable analysis of cellular pathway inhibition of a Nedd8-activating enzyme inhibitor, MLN4924, using AlphaScreen
Zhong-Hua Yan et al.
ANALYTICAL BIOCHEMISTRY (2013)
Ubiquitin Ligases and Cell Cycle Control
Leonardo K. Teixeira et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 82 (2013)
Structures of Atg7-Atg3 and Atg7-Atg10 reveal noncanonical mechanisms of E2 recruitment by the autophagy E1
Stephen E. Kaiser et al.
AUTOPHAGY (2013)
Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRASG12D-driven lung tumors
Jessie Yanxiang Guo et al.
AUTOPHAGY (2013)
Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors
Ashutosh Kumar et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Neddylation plays an important role in the regulation of murine and human dendritic cell function
Nathan Mathewson et al.
BLOOD (2013)
KAVA Chalcone, Flavokawain A, Inhibits Urothelial Tumorigenesis in the UPII-SV40T Transgenic Mouse Model
Zhongbo Liu et al.
CANCER PREVENTION RESEARCH (2013)
Novel DNA Damage Checkpoints Mediating Cell Death Induced by the NEDD8-Activating Enzyme Inhibitor MLN4924
Jonathan L. Blank et al.
CANCER RESEARCH (2013)
Sulfur Amino Acids Regulate Translational Capacity and Metabolic Homeostasis through Modulation of tRNA Thiolation
Sunil Laxman et al.
CELL (2013)
Profiling of Ubiquitin-like Modifications Reveals Features of Mitotic Control
Yifat Merbl et al.
CELL (2013)
Autophagy-Mediated Tumor Promotion
Jessie Yanxiang Guo et al.
CELL (2013)
Absolute Quantification of E1, Ubiquitin-Like Proteins and Nedd8-MLN4924 Adduct by Mass Spectrometry
Xiaofeng Yang et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2013)
Phage Display to Identify Nedd8-Mimicking Peptides as Inhibitors of the Nedd8 Transfer Cascade
Bo Zhao et al.
CHEMBIOCHEM (2013)
A Negative Feedback of the HIF-1α Pathway via Interferon-Stimulated Gene 15 and ISGylation
Yen-Hsiu Yeh et al.
CLINICAL CANCER RESEARCH (2013)
Disrupting Protein NEDDylation with MLN4924 Is a Novel Strategy to Target Cisplatin Resistance in Ovarian Cancer
Steffan T. Nawrocki et al.
CLINICAL CANCER RESEARCH (2013)
From Bortezomib to other Inhibitors of the Proteasome and Beyond
Daniela Buac et al.
CURRENT PHARMACEUTICAL DESIGN (2013)
Building and remodelling Cullin-RING E3 ubiquitin ligases - 'Ubiquitylation: mechanism and functions' review series
John R. Lydeard et al.
EMBO REPORTS (2013)
Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy
Hitoshi Nakatogawa
AUTOPHAGY: MOLECULES AND MECHANISMS (2013)
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
Jessie Yanxiang Guo et al.
GENES & DEVELOPMENT (2013)
Ubiquitin E3 Ligase CRL4CDT2/DCAF2 as a Potential Chemotherapeutic Target for Ovarian Surface Epithelial Cancer
Wei-Wei Pan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Identification of Sumoylation Activating Enzyme 1 Inhibitors by Structure-Based Virtual Screening
Ashutosh Kumar et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2013)
Development of Activity-Based Probes for Ubiquitin and Ubiquitin-like Protein Signaling Pathways
Heeseon An et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Overcoming Platinum Resistance in Preclinical Models of Ovarian Cancer Using the Neddylation Inhibitor MLN4924
Amir A. Jazaeri et al.
MOLECULAR CANCER THERAPEUTICS (2013)
Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer
Shaun K. Olsen et al.
MOLECULAR CELL (2013)
Regulation of DNA Damage Responses by Ubiquitin and SUMO
Stephen P. Jackson et al.
MOLECULAR CELL (2013)
Autophagy in Human Health and Disease REPLY
Augustine M. K. Choi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia
F. Lo-Coco et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells
C. Mackintosh et al.
ONCOGENE (2013)
Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms
M. E. Law et al.
ONCOGENE (2013)
Profiling the Cross Reactivity of Ubiquitin with the Nedd8 Activating Enzyme by Phage Display
Bo Zhao et al.
PLOS ONE (2013)
Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress
C. Bassi et al.
SCIENCE (2013)
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
Daniel Martinez Molina et al.
SCIENCE (2013)
Interferon-induced ISG15 pathway: an ongoing virus-host battle
Chen Zhao et al.
TRENDS IN MICROBIOLOGY (2013)
Largazole Arrests Cell Cycle at G1 Phase and Triggers Proteasomal Degradation of E2F1 in Lung Cancer Cells
Li-Chuan Wu et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors
Anne M. Strohecker et al.
CANCER DISCOVERY (2013)
MECHANISMS OF DISEASE Autophagy in Human Health and Disease
Augustine M. K. Choi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Cancer drug resistance: an evolving paradigm
Caitriona Holohan et al.
NATURE REVIEWS CANCER (2013)
Ubiquitin-Like Proteins
Annemarthe G. van der Veen et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)
Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening
Hai-Jing Zhong et al.
BIOCHIMIE (2012)
Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus
Rumi Yamanokuchi et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2012)
Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents
Sajal K. Ghosh et al.
BLOOD (2012)
Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924
Michael A. Milhollen et al.
CANCER CELL (2012)
Radiosensitization of Human Pancreatic Cancer Cells by MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor
Dongping Wei et al.
CANCER RESEARCH (2012)
The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth
Zhongguang Luo et al.
CANCER RESEARCH (2012)
The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions
Orsolya Leidecker et al.
CELL CYCLE (2012)
Development and Use of Integral Assays in Clinical Trials
Richard L. Schilsky et al.
CLINICAL CANCER RESEARCH (2012)
Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications
Simone Fulda et al.
EMBO MOLECULAR MEDICINE (2012)
NF-κB and the link between inflammation and cancer
Joseph A. DiDonato et al.
IMMUNOLOGICAL REVIEWS (2012)
Mechanistic Studies on Activation of Ubiquitin and Di-ubiquitin-like Protein, FAT10, by Ubiquitin-like Modifier Activating Enzyme 6, Uba6
James M. Gavin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Dual Role of the Molybdenum Cofactor Biosynthesis Protein MOCS3 in tRNA Thiolation and Molybdenum Cofactor Biosynthesis in Humans
Mita Mullick Chowdhury et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Autophagy-related Gene 7 (ATG7) and Reactive Oxygen Species/Extracellular Signal-regulated Kinase Regulate Tetrandrine-induced Autophagy in Human Hepatocellular Carcinoma
Ke Gong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15
Young Joo Jeon et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents
Younghoon Kee et al.
MOLECULAR CANCER RESEARCH (2012)
Molecular and Cellular Effects of NEDD8-Activating Enzyme Inhibition in Myeloma
Douglas W. McMillin et al.
MOLECULAR CANCER THERAPEUTICS (2012)
The Ubiquitin-Proteasome System Meets Angiogenesis
Nader Rahimi
MOLECULAR CANCER THERAPEUTICS (2012)
Largazole: From discovery to broad-spectrum therapy
Jiyong Hong et al.
NATURAL PRODUCT REPORTS (2012)
Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7
Masaya Yamaguchi et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures
Stephen E. Kaiser et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Largazole and Its Derivatives Selectively Inhibit Ubiquitin Activating Enzyme (E1)
Dana Ungermannova et al.
PLOS ONE (2012)
The p21-Dependent Radiosensitization of Human Breast Cancer Cells by MLN4924, an Investigational Inhibitor of NEDD8 Activating Enzyme
Dong Yang et al.
PLOS ONE (2012)
Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program
Malcolm A. Smith et al.
PEDIATRIC BLOOD & CANCER (2012)
A Metal-Based Inhibitor of NEDD8-Activating Enzyme
Hai-Jing Zhong et al.
PLOS ONE (2012)
Transcriptional Regulation of the Ufm1 Conjugation System in Response to Disturbance of the Endoplasmic Reticulum Homeostasis and Inhibition of Vesicle Trafficking
Yinghua Zhang et al.
PLOS ONE (2012)
A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis
Jessica D. Kessler et al.
SCIENCE (2012)
Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress
In Hye Lee et al.
SCIENCE (2012)
Protein degradation and the stress response
Karin Flick et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)
Curing APL through PML/RARA degradation by As2O3
Valerie Lallemand-Breitenbach et al.
TRENDS IN MOLECULAR MEDICINE (2012)
Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis
Y. Zhao et al.
CELL DEATH & DISEASE (2012)
A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924
Julia I. Toth et al.
CELL REPORTS (2012)
Identification and Mechanistic Studies of a Novel Ubiquitin E1 Inhibitor
Dana Ungermannova et al.
JOURNAL OF BIOMOLECULAR SCREENING (2012)
FAT10 modifies p53 and upregulates its transcriptional activity
Tianwei Li et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2011)
Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation
Monika Mortensen et al.
AUTOPHAGY (2011)
Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity
Vaibhav Kapuria et al.
BIOCHEMICAL PHARMACOLOGY (2011)
Inhibition of NEDD8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover
Michael A. Milhollen et al.
CANCER RESEARCH (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity
Maren H. Stindt et al.
CELL CYCLE (2011)
Autophagy in the pathogenesis of myelodysplastic syndrome and acute myeloid leukemia
Alexander Scarth Watson et al.
CELL CYCLE (2011)
A natural product-like inhibitor of NEDD8-activating enzyme
Chung-Hang Leung et al.
CHEMICAL COMMUNICATIONS (2011)
Ubiquitin-proteasome pathway and cellular responses to oxidative stress
Fu Shang et al.
FREE RADICAL BIOLOGY AND MEDICINE (2011)
Autophagy-deficient mice develop multiple liver tumors
Akito Takamura et al.
GENES & DEVELOPMENT (2011)
Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues
Jesse J. Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Structure of Ubiquitin-fold Modifier 1-specific Protease UfSP2
Byung Hak Ha et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
Monika Mortensen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Novel Proteasome Inhibitors to Overcome Bortezomib Resistance
Amy M. Ruschak et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2011)
The NEDD8-Activating Enzyme Inhibitor, MLN4924, Cooperates with TRAIL to Augment Apoptosis through Facilitating c-FLIP Degradation in Head and Neck Cancer Cells
Liqun Zhao et al.
MOLECULAR CANCER THERAPEUTICS (2011)
Atg8 Transfer from Atg7 to Atg3: A Distinctive E1-E2 Architecture and Mechanism in the Autophagy Pathway
Asad M. Taherbhoy et al.
MOLECULAR CELL (2011)
Structural Basis of Atg8 Activation by a Homodimeric E1, Atg7
Nobuo N. Noda et al.
MOLECULAR CELL (2011)
Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets
Lynn Bedford et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
The spatial and temporal organization of ubiquitin networks
Caroline Grabbe et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death
Domagoj Vucic et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8
Seung Beom Hong et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells
Weidong Han et al.
PLOS ONE (2011)
Inactivation of SAG E3 Ubiquitin Ligase Blocks Embryonic Stem Cell Differentiation and Sensitizes Leukemia Cells to Retinoid Acid
Mingjia Tan et al.
PLOS ONE (2011)
Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress
Matthew D. Petroski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier
Annemarthe G. Van der Veen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice
Kanako Tatsumi et al.
NATURE COMMUNICATIONS (2011)
The dual role of ubiquitin-like protein Urm1 as a protein modifier and sulfur carrier
Fengbin Wang et al.
PROTEIN & CELL (2011)
Induction of p21-Dependent Senescence by an NAE Inhibitor, MLN4924, as a Mechanism of Growth Suppression
Lijun Jia et al.
NEOPLASIA (2011)
A continuous kinetic assay for adenylation enzyme activity and inhibition
Daniel J. Wilson et al.
ANALYTICAL BIOCHEMISTRY (2010)
Mechanisms, regulation and consequences of protein SUMOylation
Kevin A. Wilkinson et al.
BIOCHEMICAL JOURNAL (2010)
ISG15 and immune diseases
Young Joo Jeon et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB-dependent lymphoma
Michael A. Milhollen et al.
BLOOD (2010)
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma
G. Wei Xu et al.
BLOOD (2010)
Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia
Ronan T. Swords et al.
BLOOD (2010)
PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3
Marion Jeanne et al.
CANCER CELL (2010)
The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1α and Bcl-2 and Activating the Beclin 1/hVps34 Complex
Xinqun Li et al.
CANCER RESEARCH (2010)
NEDD8-Targeting Drug MLN4924 Elicits DNA Rereplication by Stabilizing Cdt1 in S Phase, Triggering Checkpoint Activation, Apoptosis, and Senescence in Cancer Cells
Jie Jessie Lin et al.
CANCER RESEARCH (2010)
ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death
Lilliana Radoshevich et al.
CELL (2010)
Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?
Philip Cohen et al.
CELL (2010)
Synthetic therapeutic peptides: science and market
Patrick Vlieghe et al.
DRUG DISCOVERY TODAY (2010)
A Novel Type of E3 Ligase for the Ufm1 Conjugation System
Kanako Tatsumi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Crystal Structure of the Human Ubiquitin-activating Enzyme 5 (UBA5) Bound to ATP MECHANISTIC INSIGHTS INTO A MINIMALISTIC E1 ENZYME
John-Paul Bacik et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor
Yanxia Liu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Designed Semisynthetic Protein Inhibitors of Ub/Ubl E1 Activating Enzymes
Xuequan Lu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
The Ubiquitin-Like Protein FAT10 Mediates NF-κB Activation
Pengfei Gong et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)
Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ
James E. Brownell et al.
MOLECULAR CELL (2010)
Active site remodelling accompanies thioester bond formation in the SUMO E1
Shaun K. Olsen et al.
NATURE (2010)
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
Ying Zhao et al.
NATURE CELL BIOLOGY (2010)
Ubiquitin signalling in DNA replication and repair
Helle D. Ulrich et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition
Jaclyn R. Gareau et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Arsenic Trioxide Controls the Fate of the PML-RARα Oncoprotein by Directly Binding PML
Xiao-Wei Zhang et al.
SCIENCE (2010)
Acute promyelocytic leukaemia: novel insights into the mechanisms of cure
Hugues de The et al.
NATURE REVIEWS CANCER (2010)
Development of a charcoal paper adenosine triphosphate: pyrophosphate exchange assay: Kinetic characterization of NEDD8 activating enzyme
Frank J. Bruzzese et al.
ANALYTICAL BIOCHEMISTRY (2009)
The Role of Ubiquitin in NF-kappa B Regulatory Pathways
Brian Skaug et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
Ji Luo et al.
CELL (2009)
ATG Systems from the Protein Structural Point of View
Nobuo N. Noda et al.
CHEMICAL REVIEWS (2009)
Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate
Isao Fukuda et al.
CHEMISTRY & BIOLOGY (2009)
Resistance to Targeted Therapies: Refining Anticancer Therapy in the Era of Molecular Oncology
Lee M. Ellis et al.
CLINICAL CANCER RESEARCH (2009)
Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer
Teresa A. Soucy et al.
CLINICAL CANCER RESEARCH (2009)
Kerriamycin B inhibits protein SUMOylation
Isao Fukuda et al.
JOURNAL OF ANTIBIOTICS (2009)
Conformational Transition Associated with E1-E2 Interaction in Small Ubiquitin-like Modifications
Jianghai Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-rasLA2 mice
Xiaoyan Yin et al.
LUNG CANCER (2009)
Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA
Sebastian Leidel et al.
NATURE (2009)
Ubiquitylation in innate and adaptive immunity
Vijay G. Bhoj et al.
NATURE (2009)
Principles of ubiquitin and SUMO modifications in DNA repair
Steven Bergink et al.
NATURE (2009)
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
Teresa A. Soucy et al.
NATURE (2009)
Targeting the ubiquitin system in cancer therapy
Daniela Hoeller et al.
NATURE (2009)
Origin and function of ubiquitin-like proteins
Mark Hochstrasser
NATURE (2009)
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways
Brenda A. Schulman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Nitric oxide prodrug JS-K inhibits ubiquitin E1 and kills tumor cells retaining wild-type p53
J. Kitagaki et al.
ONCOGENE (2009)
Expression, regulation and function of the ISGylation system in prostate cancer
A. Kiessling et al.
ONCOGENE (2009)
Ubiquitin-mediated regulation of apoptosis
Melke Broemer et al.
TRENDS IN CELL BIOLOGY (2009)
SUMO, hypoxia and the regulation of metabolism
Terence A. Agbor et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins
Jennifer Schmitz et al.
BIOCHEMISTRY (2008)
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-κBα kinase, leading to potentiation of apoptosis
Bokyung Sung et al.
BLOOD (2008)
Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes
Imsang Lee et al.
CELL (2008)
Urm1 at the crossroad of modifications 'Protein Modifications: Beyond the Usual Suspects' Review Series
Patrick G. A. Pedrioli et al.
EMBO REPORTS (2008)
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy
Jiefei Geng et al.
EMBO REPORTS (2008)
Structural basis for Ufm1 processing by UfSP1
Byung Hak Ha et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
UBE1DC1, an ubiquitin-activating enzyme, activates two different ubiquitin-like proteins
Mei Zheng et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2008)
Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.
Kanchan Taori et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
UBE1L causes lung cancer growth suppression by targeting cyclin D1
Qing Feng et al.
MOLECULAR CANCER THERAPEUTICS (2008)
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
Michael H. Tatham et al.
NATURE CELL BIOLOGY (2008)
Arsenic degrades PML or PML - RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway
Valerie Lallemand-Breitenbach et al.
NATURE CELL BIOLOGY (2008)
The Polycomb Repressive Complex 2 Is a Potential Target of SUMO Modifications
Eva Madi Riising et al.
PLOS ONE (2008)
A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway
Christian D. Schlieker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Activating the ubiquitin family: UBA6 challenges the field
Marcus Groettrup et al.
TRENDS IN BIOCHEMICAL SCIENCES (2008)
E1 Ubiquitin-Activating Enzyme UBA-1 Plays Multiple Roles throughout C. elegans Development
Madhura Kulkarni et al.
PLOS GENETICS (2008)
E1 Ubiquitin-Activating Enzyme UBA-1 Plays Multiple Roles throughout C-elegans Development
Madhura Kulkarni et al.
PLOS GENETICS (2008)
Interferon-inducible antiviral effectors
Anthony J. Sadler et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
Rosa Bernardi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Evaluation of the 3p21.3 tumour-suppressor gene cluster
L. B. Hesson et al.
ONCOGENE (2007)
Crystal structure of Ufc1, the Ufm1-conjugating enzyme
Tsunehiro Mizushima et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics
Yili Yang et al.
CANCER RESEARCH (2007)
E1-L2 activates both ubiquitin and FAT10
Yu-Hsin Chiu et al.
MOLECULAR CELL (2007)
UBE1L2, a novel E1 enzyme specific for ubiquitin
Christiane Pelzer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The intrinsic affinity between E2 and the cys domain of E1 in ubiquitin-like modifications
Jianghai Wang et al.
MOLECULAR CELL (2007)
JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells
Tanyel Kiziltepe et al.
BLOOD (2007)
Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging
Jianping Jin et al.
NATURE (2007)
A metastatic signature in entire lung adenocarcinomas irrespective of morphological heterogeneity
Kentaro Inamura et al.
HUMAN PATHOLOGY (2007)
Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity
Danny T. Huang et al.
NATURE (2007)
Ubiquitin and ubiquitin-like proteins in cancer pathogenesis
Daniela Hoeller et al.
NATURE REVIEWS CANCER (2006)
Solution structure of Urm1 and its implications for the origin of protein modifiers
Junjie Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Mechanisms of Disease: oncogene addiction - a rationale for molecular targeting in cancer therapy
I. Bernard Weinstein et al.
NATURE CLINICAL PRACTICE ONCOLOGY (2006)
Drug discovery in the ubiquitin-proteasome system
Grzegorz Nalepa et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis
Cho-Rok Jung et al.
NATURE MEDICINE (2006)
FAT10/diubiquitin-like protein-deficient mice exhibit minimal phenotypic differences
Allon Canaan et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Ubiquitin ligases: cell-cycle control and cancer
KI Nakayama et al.
NATURE REVIEWS CANCER (2006)
Regulation of DNA repair by ubiquitylation
TT Huang et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes
G Bossis et al.
MOLECULAR CELL (2006)
Elevated expression of IS615 in tumor cells interferes with the ubiquitin/26S proteasome pathway
SD Desai et al.
CANCER RESEARCH (2006)
The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains
Lakshminarayan M. Iyer et al.
GENOME BIOLOGY (2006)
Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme
T Takeuchi et al.
JOURNAL OF BIOCHEMISTRY (2005)
Isolation and characterization of ubiquitin-activating enzyme E1-domain containing 1, UBE1DC1
TH Dou et al.
MOLECULAR BIOLOGY REPORTS (2005)
Ubiquitin and ubiquitin-like proteins as multifunctional signals
RL Welchman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Crystal structure of the interferon-induced ubiquitin-like protein ISG15
J Narasimhan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice
XL Zi et al.
CANCER RESEARCH (2005)
Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1
LM Lois et al.
EMBO JOURNAL (2005)
Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation
CH Uchida et al.
EMBO JOURNAL (2005)
Himeic acid A:: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp.
S Tsukamoto et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Proteolysis: from the lysosome to ubiquitin and the proteasome
A Ciechanover
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia
I Pitha-Rowe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Ubiquitin-like protein activation
DT Huang et al.
ONCOGENE (2004)
A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8
DT Huang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
A mechanism for inhibiting the SUMO pathway
R Boggio et al.
MOLECULAR CELL (2004)
Constitutive NF-kappa B DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway
KU Birkenkamp et al.
LEUKEMIA (2004)
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
L Yu et al.
SCIENCE (2004)
Microarray analyses uncover UBE1L as a candidate target gene for lung cancer chemoprevention
I Pitha-Rowe et al.
CANCER RESEARCH (2004)
Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation
KI Kim et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-α/β-induced ubiquitin-like protein
C Zhao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier
M Komatsu et al.
EMBO JOURNAL (2004)
Nuclear and unclear functions of SUMO
JS Seeler et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Conservation in the mechanism of nedd8 activation by the human AppBp1-Uba3 heterodimer
RN Bohnsack et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A superfamily of protein tags: ubiquitin, SUMO and related modifiers
DC Schwartz et al.
TRENDS IN BIOCHEMICAL SCIENCES (2003)
Expression of the FAT 10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers
CGL Lee et al.
ONCOGENE (2003)
fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence
TG Rossman et al.
ONCOGENE (2003)
Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8
H Walden et al.
NATURE (2003)
Inhibiting the p53-MDM2 interaction:: An important target for cancer therapy
P Chène
NATURE REVIEWS CANCER (2003)
Proteasomes modulate conjugation to the ubiquitin-like protein, ISG15
MJ Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1
H Walden et al.
MOLECULAR CELL (2003)
Distinct monoubiquitin signals in receptor endocytosis
K Haglund et al.
TRENDS IN BIOCHEMICAL SCIENCES (2003)
Panepophenanthrin, from a mushroom strain, a novel inhibitor of the ubiquitin-activating enzyme
R Sekizawa et al.
JOURNAL OF NATURAL PRODUCTS (2002)
Glivec (ST1571, Imatinib), a rationally developed, targeted anticancer drug
R Capdeville et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
Protein kinases - the major drug targets of the twenty-first century?
P Cohen
NATURE REVIEWS DRUG DISCOVERY (2002)
UBP43 (USP18) specifically removes ISG15 from conjugated proteins
MP Malakhov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
UBE1L is a retinoid target that triggers PML/RARα degradation and apoptosis in acute promyelocytic leukemia
S Kitareewan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex
MW Lake et al.
NATURE (2001)
Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases
AK Forrest et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)
A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes
K Furukawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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