Journal
ADVANCED THERAPEUTICS
Volume 4, Issue 2, Pages -Publisher
WILEY
DOI: 10.1002/adtp.202000203
Keywords
coronavirus; cystic fibrosis; lung cancer; nanotherapeutics; targeted delivery
Categories
Funding
- National Institutes of Health (NIH) [R01 CA238871, R01 CA209818]
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Nanocarrier-based therapeutics offer promising opportunities for treating lung diseases by encapsulating different substances, targeting specific locations, and reducing adverse effects.
Systemic delivery of therapeutics for treatment of lung diseases has several limitations including poor organ distribution of delivered payload with relatively low accumulation of active substances in the lungs and severe adverse side effects. In contrast, nanocarrier based therapeutics provide a broad range of opportunities due to their ability to encapsulate substances with different aqueous solubility, transport distinct types of cargo, target therapeutics specifically to the deceased organ, cell, or cellular organelle limiting adverse side effects and increasing the efficacy of therapy. Moreover, many nanotherapeutics can be delivered by inhalation locally to the lungs avoiding systemic circulation. In addition, nanoscale based delivery systems can be multifunctional, simultaneously carrying out several tasks including diagnostics, treatment and suppression of cellular resistance to the treatment. Nanoscale delivery systems improve the clinical efficacy of conventional therapeutics allowing new approaches for the treatment of respiratory diseases which are difficult to treat or possess intrinsic or acquired resistance to treatment. The present review summarizes recent advances in the development of nanocarrier based therapeutics for local and targeted delivery of drugs, nucleic acids and imaging agents for diagnostics and treatment of various diseases such as cancer, cystic fibrosis, and coronavirus.
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