Journal
JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
Volume 34, Issue 3, Pages 905-915Publisher
WILEY
DOI: 10.1111/jar.12849
Keywords
Alzheimer' s disease; dementia; down syndrome; mild cognitive impairment; NTG‐ EDSD
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Funding
- National Institute on Aging [U01AG051412]
- New York State Office for People with Developmental Disabilities
- National Institutes of Health Research Centers [P30AG062421, P50AG008702, U54HD079123, UL1TR001414, UL1TR001873]
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The NTG-EDSD showed sensitivity in evaluating MCI-DS, but additional sources of information are needed to achieve an acceptable level of diagnostic/screening accuracy.
Background The accuracy of the National Task Group-Early Detection Screen for Dementia (NTG-EDSD) was evaluated in a sample of 185 adults with Down syndrome (DS), emphasizing 'mild cognitive impairment (MCI-DS)'. Method Knowledgeable informants were interviewed with the NTG-EDSD, and findings were compared to an independent dementia status rating based on consensus review of detailed assessments of cognition, functional abilities and health status (including physician examination). Results Results indicated that sections of the NTG-EDSD were sensitive to MCI-DS, with one or more concerns within the 'Memory' or 'Language and Communication' domains being most informative. Conclusions The NTG-EDSD is a useful tool for evaluating dementia status, including MCI-DS. However, estimates of sensitivity and specificity, even for detecting frank dementia, indicated that NTG-EDSD findings need to be supplemented by additional sources of relevant information to achieve an acceptable level of diagnostic/screening accuracy.
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