4.6 Article

Engineered Hierarchical CuO Nanoleaves Based Electrochemical Nonenzymatic Biosensor for Glucose Detection

Journal

JOURNAL OF THE ELECTROCHEMICAL SOCIETY
Volume 168, Issue 1, Pages -

Publisher

ELECTROCHEMICAL SOC INC
DOI: 10.1149/1945-7111/abd515

Keywords

Nanoscale materials; Sensors; Nanoclusters

Funding

  1. Department of Biotechnology (DBT), Government of India
  2. JSPS KAKENHI [JP17H01224, JP18H05471, JP19H01122]
  3. JST COI [JPMJCE1314]
  4. JST -OPERA Program [JPMJOP1844, JPMJOP1614]
  5. Cabinet Office (CAO), Cross-ministerial Strategic Innovation Promotion Program (SIP), An intelligent knowledge processing infrastructure, integrating physical and virtual domains (NEDO)
  6. Department of Biotechnology, Government of India

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In this study, hierarchical CuO nanoleaves were successfully synthesized and utilized in a nonenzymatic glucose biosensor, demonstrating superior electrochemical catalytic behavior. The sensor shows high sensitivity, wide linear range, low detection limit, and good selectivity, reproducibility, and stability under laboratory conditions.
In this study, we synthesized hierarchical CuO nanoleaves in large-quantity via the hydrothermal method. We employed different techniques to characterize the morphological, structural, optical properties of the as-prepared hierarchical CuO nanoleaves sample. An electrochemical based nonenzymatic glucose biosensor was fabricated using engineered hierarchical CuO nanoleaves. The electrochemical behavior of fabricated biosensor towards glucose was analyzed with cyclic voltammetry (CV) and amperometry (i-t) techniques. Owing to the high electroactive surface area, hierarchical CuO nanoleaves based nonenzymatic biosensor electrode shows enhanced electrochemical catalytic behavior for glucose electro-oxidation in 100 mM sodium hydroxide (NaOH) electrolyte. The nonenzymatic biosensor displays a high sensitivity (1467.32 mu A/(mM cm(2))), linear range (0.005-5.89 mM), and detection limit of 12 nM (S/N = 3). Moreover, biosensor displayed good selectivity, reproducibility, repeatability, and stability at room temperature over three-week storage period. Further, as-fabricated nonenzymatic glucose biosensors were employed for practical applications in human serum sample measurements. The obtained data were compared to the commercial biosensor, which demonstrates the practical usability of nonenzymatic glucose biosensors in real sample analysis.

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