4.7 Article

Pt@polydopamine nanoparticles as nanozymes for enhanced photodynamic and photothermal therapy

Journal

CHEMICAL COMMUNICATIONS
Volume 57, Issue 2, Pages 255-258

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc07355e

Keywords

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Funding

  1. National Key R&D Program of China [2018YFE0205400]
  2. National Natural Science Foundation of China [21673056, 21972033, 21961142022]
  3. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety [NSKF202006]
  4. China Post-doctoral Science Foundation [2019M652361]
  5. Postdoctoral Innovation Program of Shandong Province [201903012]

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Polydopamine nanoparticles were utilized to stabilize a nano-Pt catalyst for relieving tumor hypoxia in photodynamic therapy (PDT). In addition to serving as a carrier for nano-Pt and photosensitizers, polydopamine also acted as a photothermal reagent in photothermal therapy (PTT). The combined PDT and PTT mechanism presented an enhanced anti-tumor therapy effect.
Polydopamine nanoparticles were used to stabilize a nano-Pt catalyst to relieve tumour hypoxia in photodynamic therapy (PDT). Polydopamine not only provides a platform for carrying nano-Pt and photosensitizers but is also used as a photothermal reagent for photothermal therapy (PTT). The system presented an enhanced anti-tumor therapy effect through a combined PDT and PTT mechanism.

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