4.7 Article

Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure

Sandor Batkai et al.

Summary: In a chronic model of post-myocardial infarction heart failure, monthly administration of CDR132L improved cardiac function, reversed cardiac remodelling, and ameliorated diastolic function, indicating its safety and therapeutic efficacy for chronic heart failure treatment.

EUROPEAN HEART JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure

Sandor Batkai et al.

Summary: The study aimed to evaluate the safety and efficacy of CDR132L in a clinically relevant large animal model of chronic heart failure after myocardial infarction. Results showed that CDR132L treatment significantly improved cardiac function and reversed cardiac remodeling, indicating its potential as a treatment for chronic heart failure.

EUROPEAN HEART JOURNAL (2021)

Article Multidisciplinary Sciences

Preclinical development of a miR-132 inhibitor for heart failure treatment

Ariana Foinquinos et al.

NATURE COMMUNICATIONS (2020)

Article Biotechnology & Applied Microbiology

Engineered Circular RNA Sponges Act as miRNA Inhibitors to Attenuate Pressure Overload-Induced Cardiac Hypertrophy

Annadoray Lavenniah et al.

MOLECULAR THERAPY (2020)

Review Medicine, General & Internal

Heart failure drug treatment

Patrick Rossignol et al.

LANCET (2019)

Review Cardiac & Cardiovascular Systems

RNA-based diagnostic and therapeutic strategies for cardiovascular disease

Dongchao Lu et al.

NATURE REVIEWS CARDIOLOGY (2019)

Article Cardiac & Cardiovascular Systems

Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure

Serge Masson et al.

EUROPEAN JOURNAL OF HEART FAILURE (2018)

Article Biochemistry & Molecular Biology

microRNA-132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease

Evgenia Salta et al.

FASEB JOURNAL (2017)

Review Biotechnology & Applied Microbiology

FDA-Approved Oligonucleotide Therapies in 2017

Cy A. Stein et al.

MOLECULAR THERAPY (2017)

Review Pharmacology & Pharmacy

Safety of antisense oligonucleotide and siRNA-based therapeutics

Xuan Chi et al.

DRUG DISCOVERY TODAY (2017)

Review Medicine, General & Internal

The war against heart failure: the Lancet lecture

Eugene Braunwald

LANCET (2015)

Article Biochemistry & Molecular Biology

Angiotensin II Regulates microRNA-132/-212 in Hypertensive Rats and Humans

Tilde V. Eskildsen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Medicine, General & Internal

Treatment of HCV Infection by Targeting MicroRNA

Harry L. A. Janssen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Multidisciplinary Sciences

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy

Ahmet Ucar et al.

NATURE COMMUNICATIONS (2012)

Article Medicine, General & Internal

Systolic Heart Failure

John J. V. McMurray

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Cardiac & Cardiovascular Systems

MicroRNAs in the human heart - A clue to fetal gene reprogramming in heart failure

Thomas Thum et al.

CIRCULATION (2007)