Journal
NUCLEIC ACIDS RESEARCH
Volume 49, Issue D1, Pages D1160-D1169Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkaa997
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Funding
- National Institutes of Health (NIH) Common Fund [U24 CA224370]
- NIH National Cancer Institute (NCI) Cancer Center Support Grant [P30 CA118100]
- NIH NCATS Clinical and Translational Science Center [UL1 TR001449]
- Intramural Research Program, Division of Preclinical Innovation, NIH NCATS
- National Science Foundation [NSF-PREM] [DMR-1827745]
- NIH [CA224370]
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DrugCentral is a public resource that offers up-to-date drug information, including newly approved drug ingredients, molecular entities related to COVID19, pharmacokinetic properties of drugs, sex-based separation of side effects, drug repositioning prioritization scheme, and machine learning platform for estimating anti-SARS-CoV-2 activities. Additionally, it provides a feature called 'drugs in news' for listing the most interesting drugs at the present moment.
DrugCentral is a public resource (http://drugcentral.org) that serves the scientific community by providing up-to-date drug information, as described in previous papers. The current release includes 109 newly approved (October 2018 through March 2020) active pharmaceutical ingredients in the US, Europe, Japan and other countries; and two molecular entities (e.g. mefuparib) of interest for COVID19. New additions include a set of pharmacokinetic properties for similar to 1000 drugs, and a sex-based separation of side effects, processed from FAERS (FDA Adverse Event Reporting System); as well as a drug repositioning prioritization scheme based on the market availability and intellectual property rights forFDA approved drugs. In the context of the COVID19 pandemic, we also incorporated REDIAL-2020, a machine learning platform that estimates anti-SARS-CoV-2 activities, as well as the `drugs in news' feature offers a brief enumeration of the most interesting drugs at the present moment. The full database dump and data files are available for download fromthe DrugCentral web portal.
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