Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 9, Issue 2, Pages 410-420Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb01880e
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Funding
- European Commission under the H2020-MSCA-ITN-2015 program [675417]
- Spanish Ministry of Economy and Competitiveness [CTQ2017-87637-R]
- Maria de Maeztu Units of Excellence Program [MDM-2017-0720]
- Marie Curie Actions (MSCA) [675417] Funding Source: Marie Curie Actions (MSCA)
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Boron neutron capture therapy (BNCT) is a promising cancer treatment that exploits the neutron capture capacity of boron-10. The development of nanocarriers capable of accumulating boron atoms in tumor cells has been encouraged by the emergence of nanotechnology. Using small-sized boron carriers and a pre-targeting strategy can enhance tumor accumulation.
Boron neutron capture therapy (BNCT) is a promising cancer treatment exploiting the neutron capture capacity and subsequent fission reaction of boron-10. The emergence of nanotechnology has encouraged the development of nanocarriers capable of accumulating boron atoms preferentially in tumour cells. However, a Long circulation time, required for high tumour accumulation, is usually accompanied by accumulation of the nanosystem in organs such as the Liver and the spleen, which may cause off-target side effects. This could be overcome by using small-sized boron carriers via a pre-targeting strategy. Here, we report the preparation, characterisation and in vivo evaluation of tetrazine-functionalised boron-rich carbon dots, which show very fast clearance and Low tumour uptake after intravenous administration in a mouse HER2 (human epidermal growth factor receptor 2)-positive tumour model. Enhanced tumour accumulation was achieved when using a pretargeting approach, which was accomplished by a highly selective biorthogonal reaction at the tumour site with trans-cyclooctene-functionahsed Trastuzumab.
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