Journal
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
Volume 46, Issue 3, Pages 449-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.gtc.2017.05.002
Keywords
Crohn's disease; Genetics; GWAS; Phenotypes; Behavior; TNF; NOD2; Genetic score
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Since the discovery of the first Crohn's disease (CD) gene NOD2 in 2001, 140 genetic loci have been found in whites using high-throughput genomewide association studies. Several genes influence the CD subphenotypes and treatment response. With the observations of increasing prevalence in Asia and developing countries and the incomplete explanation of CD variance, other underexplored areas need to be integrated through novel methodologies. Algorithms that incorporate specific genetic risk alleles with other biomarkers will be developed and used to predict CD disease course, complications, and response to specific therapies, allowing precision medicine to become real in CD.
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