Journal
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
Volume 46, Issue 4, Pages 839-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.gtc.2017.08.006
Keywords
Stress; Depression; Anxiety; Brain-gut axis; Vagus nerve; Gut microbiota
Categories
Funding
- Bingham Chair in Gastroenterology
- Abbvie Canada
- Shire Canada
- Takeda Canada
- Janssen Canada
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The brain-gut axis serves as a circuit that incorporates the human experience, the state of mind, the gut microbiome, and the immune response that ultimately drives the phenotypic expression of inflammatory bowel disease (IBD). There are several biological pathways through which stress can play a deleterious role, including through increasing intestinal permeability, which can facilitate intestinal translocation of bacteria. Stress has an impact on symptoms in IBD; however, there is limited evidence that stress triggers increased intestinal inflammation. Although attention to stress and psychiatric comorbidity is important in the management of IBD, there are few clinical trials to direct management.
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