Journal
VIRUS EVOLUTION
Volume 7, Issue 1, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ve/veab006
Keywords
SARS-CoV-2; COVID-19; primers; next generation sequencing
Categories
Funding
- Uganda Ministry of Health
- National COVID-19 Task Force
- UK MRC
- UK DFID
- European Union
- UK Research and Innovation/MRC
- Global Fund
- Government of Uganda
- GAVI
- Islamic Development Bank
- UK MRC
- World Health Organization
- US Centers for Disease Control and Prevention
- Jack Ma Foundation
- Marie Sklodowska-Curie Individual Fellowship - European Union
- Wellcome Epidemic Preparedness-Coronavirus grant - Wellcome Trust
- [799417]
- [NC_PC_19060]
- [220977/Z/20/Z]
- [MC_EX_MR/L016273/1]
Ask authors/readers for more resources
Global efforts to sequence the SARS-CoV-2 genome are hindered by gaps in approximately 19 to 43 per cent of monthly generated sequences. This study provides an alternative primer set and sequencing scheme to improve the quality and coverage of genomes, aiding in the development of effective control measures.
As the world is struggling to control the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), there is an urgency to develop effective control measures. Essential information is encoded in the virus genome sequence with accurate and complete SARS-CoV-2 sequences essential for tracking the movement and evolution of the virus and for guiding efforts to develop vaccines and antiviral drugs. While there is unprecedented SARS-CoV-2 sequencing efforts globally, approximately 19 to 43 per cent of the genomes generated monthly are gapped, reducing their information content. The current study documents the genome gap frequencies and their positions in the currently available data and provides an alternative primer set and a sequencing scheme to help improve the quality and coverage of the genomes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available