Journal
LAB ON A CHIP
Volume 21, Issue 2, Pages 234-253Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0lc00799d
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Funding
- Italian Ministry of Health, Current Research Project [2 - 8ARC]
- H2020 ERC-2017-PoC Grant [779751]
- European Research Council (ERC) [779751] Funding Source: European Research Council (ERC)
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Immunotherapy is a powerful therapeutic approach that re-educates the immune system to fight cancer, with the tumor microenvironment playing a key role in the process. Microfluidic devices offer a unique technological approach for studying cancer-immune system interactions, highlighting the significance of the vascular component in immune trafficking.
Immunotherapy is a powerful therapeutic approach able to re-educate the immune system to fight cancer. A key player in this process is the tumor microenvironment (TME), which is a dynamic entity characterized by a complex array of tumor and stromal cells as well as immune cell populations trafficking to the tumor site through the endothelial barrier. Recapitulating these multifaceted dynamics is critical for studying the intimate interactions between cancer and the immune system and to assess the efficacy of emerging immunotherapies, such as immune checkpoint inhibitors (ICIs) and adoptive cell-based products. Microfluidic devices offer a unique technological approach to build tumor-on-a-chip reproducing the multiple layers of complexity of cancer-immune system crosstalk. Here, we seek to review the most important biological and engineering developments of microfluidic platforms for studying cancer-immune system interactions, in both solid and hematological tumors, highlighting the role of the vascular component in immune trafficking. Emphasis is given to image processing and related algorithms for real-time monitoring and quantitative evaluation of the cellular response to microenvironmental dynamic changes. The described approaches represent a valuable tool for preclinical evaluation of immunotherapeutic strategies.
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