Journal
THERANOSTICS
Volume 11, Issue 7, Pages 3183-3195Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.52570
Keywords
Exosomes; targeted delivery; chemical modification; genetic engineering; exosomal membrane proteins
Categories
Funding
- Shenzhen Science and Technology Projects [JCYJ20200109150700942, JCYJ20180306170922163, KQTD20170331100838136]
- Samming Project of Medicine in Shenzhen [SZSM201612079]
- Key Realm R&D Program of Guangdong Province [2019B030335001]
- Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties [SZGSP013, SZGSP007]
- Shenzhen Key Medical Discipline Construction Fund [SZXK042]
- Natural Science Foundation of Guangdong Province [2020A1515011581, 2018B0303110003]
- University Grants Committee of Hong Kong (GRF) [N_CUHK422/18]
- CUHK RSFS
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Exosomes can be engineered through genetic and chemical methods for targeted drug delivery, increasing the local concentration of therapeutics and minimizing side effects.
Exosomes are cell-derived nanovesicles that are involved in the intercellular transportation of materials. Therapeutics, such as small molecules or nucleic acid drugs, can be incorporated into exosomes and then delivered to specific types of cells or tissues to realize targeted drug delivery. Targeted delivery increases the local concentration of therapeutics and minimizes side effects. Here, we present a detailed review of exosomes engineering through genetic and chemical methods for targeted drug delivery. Although still in its infancy, exosome-mediated drug delivery boasts low toxicity, low immunogenicity, and high engineerability, and holds promise for cell-free therapies for a wide range of diseases.
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