Journal
GASTROENTEROLOGY
Volume 152, Issue 8, Pages 1845-1875Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2017.03.035
Keywords
Specificity Protein; Kruppel-Like Factor; Digestive System; Cancer; Stem Cells; Proliferation; Differentiation; Development; Apoptosis; Cell Cycle
Categories
Funding
- National Institutes of Health [DK052230, DK093680, CA084197, CA172113, F30CA206240]
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Specificity proteins (SPs) and Kruppel-like factors (KLFs) belong to the family of transcription factors that contain conserved zinc finger domains involved in binding to target DNA sequences. Many of these proteins are expressed in different tissues and have distinct tissue-specific activities and functions. Studies have shown that SPs and KLFs regulate not only physiological processes such as growth, development, differentiation, proliferation, and embryogenesis, but pathogenesis of many diseases, including cancer and inflammatory disorders. Consistently, these proteins have been shown to regulate normal functions and pathobiology in the digestive system. We review recent findings on the tissue-and organ-specific functions of SPs and KLFs in the digestive system including the oral cavity, esophagus, stomach, small and large intestines, pancreas, and liver. We provide a list of agents under development to target these proteins.
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