Journal
ANALYTICAL METHODS
Volume 13, Issue 1, Pages 117-123Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ay01996h
Keywords
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Funding
- Project of Innovation Platform for Fuzhou Health and Family Planning Commission [2017-S-wp1, 2018-S-wp3]
- Key Clinical Specialty Discipline Construction Program of Fujian Province
- Major Science and Technology Projects of Fuzhou (2017)
- Funds for Young and Middle-aged Experts with Outstanding Contributions to Health and Family Planning in Fujian Province (2017-2018)
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In this study, nitrogen-doped hollow nanocarbon spheres were prepared by using dopamine as a carbon and nitrogen source, and were utilized to construct a new electrochemical sensor for methotrexate (MTX). The sensor showed excellent sensitivity, a wide linear range, low detection limit, and good reproducibility, stability, and selectivity for MTX detection.
As an antineoplastic drug, methotrexate (MTX) is widely applied in cancer therapies; however it has potentially toxic activity, and thus the qualitative and quantitative determination of MTX is of great significance. In this paper, by using dopamine synchronously as a carbon and N source, N-doped hollow nanocarbon sphere (NHNC) hybrids were prepared via a simple self-polymerization method and used to construct a new electrochemical sensor for MTX. The prepared NHNC exhibits a uniform hollow nanostructure with high conductivity and electrocatalytic properties as well as large adsorption capacity and surface area, which are the key factors for improving the sensor sensitivity of MTX. For achieving highly sensitive determination of MTX, various conditions were optimized, and the final results show that the NHNC modified electrode has excellent sensing responses for MTX, and it has a wide linear range from 0.05 to 14.0 mu M coupled with a low detection limit of 0.01 mu M. Finally, studies on the reproducibility, stability and selectivity of the NHNC modified electrode show that the corresponding results are satisfactory.
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