4.7 Article

The first step of arsenoplatin-1 aggregation in solution unveiled by solving the crystal structure of its protein adduct

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Summary: Pt-based drugs are widely used in cancer treatment, with their mechanisms of action depending on interactions with DNA. Proteins' recognition of these metal compounds plays a crucial role in pharmacokinetics, side effects, and overall pharmacological profiles. Single crystal X-ray diffraction studies provide valuable insights into the molecular mechanisms underlying this process, revealing that metal ligands and non-covalent interactions drive the reaction of Pt compounds with proteins. Metalated protein structures coordinate few protein side chains upon releasing labile ligands, highlighting the importance of early-stage non-covalent interactions in defining the structure of the final Pt-protein adduct.

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