Journal
NEW JOURNAL OF CHEMISTRY
Volume 45, Issue 1, Pages 32-35Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nj04889e
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Funding
- Ministry of Education (MOE) AcRF Tier 1 funding [2019-T1-002-114]
- Nanyang Technological University (SUG)
- Agency for Science Technology and Research (A*STAR)
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Conducting miniaturized reactions in parallel can increase laboratory productivity without depleting high value reagents. Coating thin layers of solid reagents with polystyrene beads offers an elegant strategy to address the microscale high throughput solid dispensing challenge. The successful utilization of Biobeads on polystyrene beads for high throughput reaction screening with nanomole quantities of ketoreductase demonstrates a promising approach for asymmetric biocatalytic reactions.
Miniaturized reactions conducted in parallel can lead to increased productivity in laboratories without depleting high value reagents. The use of polystyrene beads to coat thin layers of solid reagents offers an elegant strategy to tackle the microscale high throughput solid dispensing conundrum. Herein we report the successful utilization of Biobeads as the first example of high throughput reaction screening with nanomole quantities of ketoreductase on polystyrene beads for asymmetric biocatalytic reactions.
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